Water → 4-[4-(O-Benzyloximino)cyclohexylamino]-3-methoxy-2-methylpyridine

HRID 1006

반응식

HRID 1006 반응식
O=[C:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH3:15])[C:10]=2[O:16][CH3:17])[CH2:4][CH2:3]1.[CH2:18]([O:25][NH2:26])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O.C(OCC)(=O)C.CO>C1(C)C=CC=CC=1>[CH2:18]([O:25][N:26]=[C:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH3:15])[C:10]=2[O:16][CH3:17])[CH2:4][CH2:3]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 102313O-BenzylhydroxylamineHCID 196939514-(4-Oxocyclohexylamino)-3-methoxy-2-methylpyridineHCID 21584119Ethylacetate methanol

생성물 1

HCID 196939734-[4-(O-Benzyloximino)cyclohexylamino]-3-methoxy-2-methylpyridine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2 g of 4-(4-oxocyclohexylamino)-3-methoxy-2-methylpyridine and 1.2 g O-benzylhydroxylamine are boiled in toluene in a water separator until liberation of water has ended. The product is isolated by column chromatography (ethyl acetate/methanol 9:1; silica gel). 1.8 g=53%

출처 및 근거

ORD 기록
ord-7b74a27dcc2940b5b3a704ddbd2de98d
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723450

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