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Hydrochloric Acid → 2-Benzhydrylpiperazine dihydrochloride

HRID 1006317
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HRID 1006317 반응식
[ClH:1].Cl.C([N:10]1[CH2:15][C:14](=O)[N:13](CC2C=CC=CC=2)[CH:12]([CH:24]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:11]1=O)C1C=CC=CC=1.Cl>CO.C(OCC)(=O)C.[C].[Pd]>[ClH:1].[ClH:1].[CH:24]([CH:12]1[CH2:11][NH:10][CH2:15][CH2:14][NH:13]1)([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 226745291,4-Dibenzyl-3-benzhydryl-2,5-piperazinedione dihydrochloride

생성물 1

HCID 226747432-Benzhydrylpiperazine dihydrochloride수율 205%

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매
HCID 8857
Ethyl Acetate
용매

실험 절차

A solution of 1,4-dibenzyl-3-benzhydryl-2,5-piperazinedione dihydrochloride (840 mg) in methanol (10 ml) was hydrogenated over 10% palladium-carbon (50% wet, 84 mg) at room temperature under atmospheric pressure for 5 hours. After removal of the catalyst by filtration, the filtrate was evaporated under reduced pressure to give an oil, which was treated with 4N hydrogen chloride in ethyl acetate solution to give 2-benzhydrylpiperazine dihydrochloride (525 mg) as a colorless powder.

후처리

  1. customAfter removal of the catalyst
  2. filtrationby filtration
  3. customthe filtrate was evaporated under reduced pressure
  4. customto give an oil, which

출처 및 근거

ORD 기록
ord-1e6b51b7810d4c96aff4fd17828bed31
출처 데이터셋
uspto-grants-2004_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06787543B2

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