Hydrochloric Acid → 4-[(4-Fluorophenyl)methyl]piperidine hydrochloride

HRID 1006374노트

반응식

HRID 1006374 반응식
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH2:11][CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[F:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][CH:12]2[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]2)=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 226766794-(4-Fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 170394924-[(4-Fluorophenyl)methyl]piperidine hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of 4N hydrogen chloride in ethyl acetate (100 ml) was added to 1-tert-butoxycarbonyl-4-(4-fluorobenzyl)piperidine (39.9 g) and the solution was stirred for an hour at room temperature. The reaction mixture was concentrated under reduced pressure, then diethyl ether was added thereto. The resulting precipitate was collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the title compound (30.1 g).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additiondiethyl ether was added
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with diethyl ether
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-5a663f4ef5e24fdaa968caa9f13ce253
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06787650B1

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