Thiourea → HCID 22671284, 화합물

HRID 1006506노트

반응식

HRID 1006506 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12])[CH2:5]Br.NC(N)=[S:17]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:5][SH:17])[CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12]

참가 물질

4

반응물 2

HCID 2723790ThioureaHCID 27738494-(Bromomethyl)-2-chloro-1-(trifluoromethoxy)benzene

생성물 1

HCID 22671284HCID 22671284, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 3-chloro-4-(trifluoromethoxy)benzylbromide (5 g) in ethanol (100 ml) was added thiourea (5 g) and the mixture heated under reflux for 2 hours. The mixture was evaporated to dryness and the residue taken up into water (100 ml). To this solution was added sodium hydroxide pellets (3 g) and the mixture heated under reflux for 1 hour. The mixture was allowed to cool to room temperature and acidified with concentrated hydrochloric acid, the mixture was extracted with ether, dried and evaporated to give the subtitle compound as a colourless waxy solid (3.5 g).

후처리

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 2 hours
  3. customThe mixture was evaporated to dryness
  4. additionTo this solution was added sodium hydroxide pellets (3 g)
  5. temperaturethe mixture heated
  6. temperatureunder reflux for 1 hour
  7. extractionthe mixture was extracted with ether
  8. customdried
  9. customevaporated

출처 및 근거

ORD 기록
ord-86ca4727cca049128d5ddab58d5558e1
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06790850B1

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