Methanol → 7-Chloro-5-[(2,3-difluorophenylmethyl)thio]-2-methoxythiazolo[4,5-d]pyrimidine

HRID 1006508노트

반응식

HRID 1006508 반응식
Br[C:2]1[S:3][C:4]2[C:9]([Cl:10])=[N:8][C:7]([S:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=3[F:20])=[N:6][C:5]=2[N:21]=1.[OH-:22].[K+].[CH3:24]O>Cl>[Cl:10][C:9]1[C:4]2[S:3][C:2]([O:22][CH3:24])=[N:21][C:5]=2[N:6]=[C:7]([S:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=2[F:20])[N:8]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 226713342-Bromo-7-chloro-5-((2,3-difluorobenzyl)thio)thiazolo[4,5-d]pyrimidine

생성물 1

HCID 226713137-Chloro-5-[(2,3-difluorophenylmethyl)thio]-2-methoxythiazolo[4,5-d]pyrimidine

시약·촉매·용매 1

HCID 313Hydrochloric Acid촉매

실험 절차

The product of example 31 step a) (5.6 g) was suspended in methanol (150 ml) and potassium hydroxide powder (0.77 g) added. The whole was stirred at room temperature for 2 hours. The mixture was adjusted to pH 7 with a few drops of concentrated hydrochloric acid before it was evaporated to dryness. Purified by column chromatography (silica-3:2 to 1:1 isohexane/dichloromethane) to give white solid (2.0 g).

후처리

  1. customwas evaporated to dryness
  2. customPurified by column chromatography (silica-3:2 to 1:1 isohexane/dichloromethane)

출처 및 근거

ORD 기록
ord-9414865e4b8044c0a4fe600fec071c31
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06790850B1

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