Ammonium Chloride → HCID 178461804, 화합물

HRID 1006511노트

반응식

HRID 1006511 반응식
[Na].[NH2:2][C:3]1[S:4][C:5]2[C:10]([NH:11][C@H:12]([CH3:15])[CH2:13][OH:14])=[N:9][C:8]([S:16]CC3C=CC=CC=3)=[N:7][C:6]=2[N:24]=1.[Cl-].[NH4+]>N>[NH2:2][C:3]1[S:4][C:5]2[C:10]([NH:11][C@H:12]([CH3:15])[CH2:13][OH:14])=[N:9][C:8]([SH:16])=[N:7][C:6]=2[N:24]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 11857680(2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

생성물 1

HCID 178461804HCID 178461804, 화합물

시약·촉매·용매 1

HCID 222Ammonia용매

실험 절차

Sodium metal was added portionwise to a solution of the product of example 32 step a) (5.0 g) in ammonia (150 ml) until a blue colouration persisted. Ammonium chloride was then added and the solvent allowed to evaporate. The residue was dissolved in H2O (200 ml) and filtered before neutralising with 2M HCl solution. The grey precipitate was filtered, washed with H2O (200 ml) and dried in vacuo for 48 h to yield the subtitle compound as a brown solid (3.0 g).

후처리

  1. customto evaporate
  2. dissolutionThe residue was dissolved in H2O (200 ml)
  3. filtrationfiltered
  4. filtrationThe grey precipitate was filtered
  5. washwashed with H2O (200 ml)
  6. customdried in vacuo for 48 h

출처 및 근거

ORD 기록
ord-c3367a14331a4c2d9b723709b62417a9
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06790850B1

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