Potassium Cyanide → 2-(2-Bromo-3-methylphenyl)acetonitrile

HRID 1006697

반응식

HRID 1006697 반응식
[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[C-:11]#[N:12].[K+]>CN(C)C=O>[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][C:11]#[N:12]

참가 물질

4

반응물 2

HCID 9032Potassium CyanideHCID 109343202-Bromo-1-(bromomethyl)-3-methylbenzene

생성물 1

HCID 226726132-(2-Bromo-3-methylphenyl)acetonitrile수율 44.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

A mixture of 2-brom-3-methylbenzylbromide (25 g, 0.095 mol) and potassium cyanide (16 g, 0.25 mol) in dimethylformamide (100 ml) was stirred at 90° C. for 20 h. The solvent was evaporated under reduced pressure and to the residue were added toluene and water. The organic layer was separated washed with water, separated and evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel using methylene chloride as eluent gave 8.8 g (44%) of the title compound.

후처리

  1. customThe solvent was evaporated under reduced pressure and to the residue
  2. additionwere added toluene and water
  3. customThe organic layer was separated
  4. washwashed with water
  5. customseparated
  6. customevaporated under reduced pressure
  7. customPurification of the residue by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-9ba3ef7949d34f6181be2d166926885e
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06790960B2

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