[H-].[Na+].Br[CH2:4][C:5]([N:7]([CH2:9][CH2:10][CH2:11][CH3:12])[CH3:8])=[O:6].[SH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19].[Cl-].[NH4+]>O1CCCC1>[CH2:9]([N:7]([CH3:8])[C:5](=[O:6])[CH2:4][S:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[CH2:10][CH2:11][CH3:12]1.4 g of sodium hydride at 50% in oil and 6 g of bromo N-butyl-N-methyl acetamide of Step A of Preparation B of Example 78 were added to a solution of 3.36 g of the product of Step A in 45 ml of tetrahydrofuran under a nitrogen atmosphere. The mixture was stirred for 2 hours at ambient temperature and poured into an ammonium chloride solution and extracted with ethyl acetate. The extracts were washed and evaporated to dryness under reduced pressure. The 10 g of residue were chromatographed on silica (eluant: cyclohexane-ethyl acetate 2-8) to obtain 5.27 g of the expected product.
불러오는 중…
