4-Chloro-3-methylphenol → 4-Chloro-3-methylphenyl acetate

HRID 1007051

반응식

HRID 1007051 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[CH3:9].[C:10](OC(=O)C)(=[O:12])[CH3:11]>S(=O)(=O)(O)O.O>[C:10]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([CH3:9])[CH:4]=1)(=[O:12])[CH3:11]

참가 물질

5

반응물 2

HCID 17324-Chloro-3-methylphenolHCID 7918Acetic Anhydride

생성물 1

HCID 5215554-Chloro-3-methylphenyl acetate

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 962Water용매

실험 절차

43.0 g (0.30 mol) of 4-chloro-3-methylphenol, 34 ml (0.36 mol) of acetic anhydride and a few drops of concentrated sulfuric acid were stirred for 2 h at 60° C. in a 250 ml flask equipped with a reflux condenser. The reaction mixture was cooled to room temperature, poured into 200 ml of water and stirred for 1 h at room temperature. The mixture was then extracted with 400 ml of diethyl ether. The organic phase was dried over magnesium sulfate and the ether was distilled off. The raw product is subsequently distilled under reduced pressure (b.p. 65-68° C., 20 mbar).

후처리

  1. customequipped with a reflux condenser
  2. extractionThe mixture was then extracted with 400 ml of diethyl ether
  3. dry with materialThe organic phase was dried over magnesium sulfate
  4. distillationthe ether was distilled off
  5. distillationThe raw product is subsequently distilled under reduced pressure (b.p. 65-68° C., 20 mbar)

출처 및 근거

ORD 기록
ord-3c8ac6c82fab4513ae93351fa237ec1b
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06793986B2

연결된 노트

불러오는 중…