Hydrochloric Acid → methyl 3-(S)-n-butyl-3-[2-(S)-carboxypyrrolidin-1-yl-carbonyl)-2-(S)-fluoropropionate

HRID 1008289노트

반응식

HRID 1008289 반응식
[CH2:1]([C@@H:5]([C:12]([N:14]1[CH2:18][CH2:17][CH2:16][C@H:15]1[C:19]([O:21]C(C)(C)C)=[O:20])=[O:13])[C@H:6]([F:11])[C:7]([O:9][CH3:10])=[O:8])[CH2:2][CH2:3][CH3:4].Cl>O1CCOCC1>[CH2:1]([C@@H:5]([C:12]([N:14]1[CH2:18][CH2:17][CH2:16][C@H:15]1[C:19]([OH:21])=[O:20])=[O:13])[C@H:6]([F:11])[C:7]([O:9][CH3:10])=[O:8])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 59908507methyl 3-(S)-n-butyl-3-[2-(S)-tert-butoxycarbonylpyrrolidin-1-ylcarbonyl)-2-(S)-fluoropropionate

생성물 1

HCID 59908494methyl 3-(S)-n-butyl-3-[2-(S)-carboxypyrrolidin-1-yl-carbonyl)-2-(S)-fluoropropionate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To methyl 3-(S)-n-butyl-3-[2-(S)-tert-butoxycarbonylpyrrolidin-1-ylcarbonyl)-2-(S)-fluoropropionate H-4 (4.3 mmol) was added 4 N HCl in dioxane (15 mL), the solution stirred for 2 h, then evaporated to dryness to afford 4.3 mmol of methyl 3-(S)-n-butyl-3-[2-(S)-carboxypyrrolidin-1-yl-carbonyl)-2-(S)-fluoropropionate H-5 (quant.). To H-5 (0.15 mmol) in dioxane (1 mL) was added an amine (0.15 mmol), DIEA (0.38 mmol), and HATU or similar coupling reagent (0.15 mmol) and the solution stirred for 8 h. The reaction was cooled to 0° C., aqueous 50% hydroxylamine was added (0.5 mL) and the reaction stirred for 4 h. The crude reaction mixture was then purified by preparative reverse-phase (C18) HPLC to afford N-hydroxy-3-(S)-n-butyl-3-[2-(S)-aminocarbonylpyrrolidin-1-yl-carbonyl)-2-(S)-fluoropropionamide H-6.

후처리

  1. customevaporated to dryness

출처 및 근거

ORD 기록
ord-c7cb9b6c3d834b459fde4c306ce54958
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06797820B2

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