Acetic Anhydride → Acetic acid 2-(1-methyl-1H-indol-7-yloxy)-ethyl ester

HRID 1009015

반응식

HRID 1009015 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[O:11][CH2:12][CH2:13][OH:14])[CH:4]=[CH:3]1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>N1C=CC=CC=1>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[O:11][CH2:12][CH2:13][O:14][C:15](=[O:17])[CH3:16])[CH:4]=[CH:3]1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 673047412-(1-Methyl-1H-indol-7-yloxy)-ethanol

생성물 1

HCID 67304991Acetic acid 2-(1-methyl-1H-indol-7-yloxy)-ethyl ester

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 2-(1-methyl-1H-indol-7-yloxy)-ethanol (0.78 g, 4 mmol) in pyridine (10 mL) was treated with acetic anhydride (5 mL). The reaction mixture was stirred at rt for 4 h and concentrated. The residue was quenched with ice/water and extracted with ethyl acetate. The organics were washed with 2N sulfuric acid, sat. sodium bicarbonate and brine, dried and concentrated. The residue was chromatographed on silica gel using heptanelethyl acetate as eluent to produce the desired compound (0.90 g) as an off-white solid. MS (ISP): m/e 234.1 (M+H)+

후처리

  1. concentrationconcentrated
  2. customThe residue was quenched with ice/water
  3. extractionextracted with ethyl acetate
  4. washThe organics were washed with 2N sulfuric acid, sat. sodium bicarbonate and brine
  5. customdried
  6. concentrationconcentrated
  7. customThe residue was chromatographed on silica gel using heptanelethyl acetate as eluent

출처 및 근거

ORD 기록
ord-6df211154aa948ef91eb957b4b6645ce
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973051B2

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