2-Bromopropiophenone → 2-Amino-4-phenyl-5-methylthiazole
반응식
Br[CH:2]([CH3:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[NH2:12][C:13]([NH2:15])=[S:14]>C(O)C>[CH3:11][C:2]1[S:14][C:13]([NH2:15])=[N:12][C:3]=1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1참가 물질
4
반응 조건
- 온도
- 57.5 °C
실험 절차
To a solution of 2-bromo-1-phenyl-propan-1-one (3.64 g, 17.1 mmol) in 30 mL of ethanol was added thiourea (1.30 g, 1.00 eq.) and the mixture vigorously stirred at 55-60° C. for 4 h. Pouring onto crashed ice/Na2CO3, twofold extraction with ethyl acetate, washing with water and brine, drying over sodium sulfate, and evaporation of the solvents, followed by crystallization from ethyl acetate/hexane, left 2.87 g of the title product as off-white crystals.
후처리
- additionPouring
- extractionice/Na2CO3, twofold extraction with ethyl acetate
- washwashing with water and brine
- dry with materialdrying over sodium sulfate, and evaporation of the solvents
- customfollowed by crystallization from ethyl acetate/hexane
- waitleft 2.87 g of the title product as off-white crystals
출처 및 근거
- ORD 기록
- ord-1d3dad42707b41e2912134afaf88456d
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07973051B2
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