tert-butyl N-(4-ethyl-5-methylsulfanyl-thiazol-2-yl)carbamate → HCID 86630962, 화합물
반응식
C(OC(=O)[NH:7][C:8]1[S:9][C:10]([S:15][CH3:16])=[C:11]([CH2:13][CH3:14])[N:12]=1)(C)(C)C>Cl>[CH2:13]([C:11]1[N:12]=[C:8]([NH2:7])[S:9][C:10]=1[S:15][CH3:16])[CH3:14]참가 물질
3
반응 조건
- 온도
- 30 °C
실험 절차
The above prepared (4-ethyl-5-methylsulfanyl-thiazol-2-yl)-carbamic acid tert-butyl ester (1.067 g, 3.888 mmol) was treated with 20 mL of HCl (4 M in dioxane). After 48 h at RT the reaction mixture was evaporated to dryness and, since still some starting material was present, the procedure repeated, but this time the temperature was raised to 30° C. Careful evaporation and drying left 0.814 g of the title compound as hydrochloride.
후처리
- customAfter 48 h at RT the reaction mixture was evaporated to dryness
- customCareful evaporation
- customdrying
- waitleft 0.814 g of the title compound as hydrochloride
출처 및 근거
- ORD 기록
- ord-d1011213f0be4f55ad73edfaaed38614
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07973051B2
반응 노트
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