Dimethylformamide → HCID 16046253, 화합물

HRID 1009177노트

반응식

HRID 1009177 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][NH:12][C:11](=[O:15])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].CN(C=O)C.[Cl:23][C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH2:26]Cl>ClCCl.O>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:26][C:25]2[CH:28]=[CH:29][CH:30]=[CH:31][C:24]=2[Cl:23])[C:11](=[O:15])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 119062-Chlorobenzyl chlorideHCID 24758Sodium hydrideHCID 36077244-Benzyloxy-2(1H)-pyridone

생성물 1

HCID 16046253HCID 16046253, 화합물수율 67%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

A solution of 4-benzyloxy-1H-pyridone (300 mg, 1.49 mmol) and NaH (60 mg, 1.49 mmol) in solvent of DMF was stirred for 30 min followed by adding 2-chlorobenzyl chloride (240 mg, 1.49 mmol) further stirring for 30 min at room temperature. The resulting solution was worked up with Water and dichloromethane and purified by column chromatography (ethyl acetate/hexane, 1:1) to obtain the titled compound (320 mg, 67%).

후처리

  1. custompurified by column chromatography (ethyl acetate/hexane, 1:1)

출처 및 근거

ORD 기록
ord-ec335de52c5c45fdbcc303b5c450145e
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973060B2

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