1-Hydroxybenzotriazole → HCID 67067277, 화합물

HRID 1009382노트

반응식

HRID 1009382 반응식
C(N(C(C)C)CC)(C)C.C1C=CC2N(O)N=NC=2C=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]([CH2:32][CH2:33][OH:34])[C:28]([NH:30][NH2:31])=[O:29])=[CH:23][CH:22]=1.[CH3:35][O:36][C:37]1[CH:38]=[C:39](/[CH:49]=[CH:50]/[C:51](O)=[O:52])[CH:40]=[CH:41][C:42]=1[N:43]1[CH:47]=[C:46]([CH3:48])[N:45]=[CH:44]1>CN(C=O)C.[Cl-].[Na+].O.C(OCC)(=O)C.C(Cl)CCl>[CH3:35][O:36][C:37]1[CH:38]=[C:39](/[CH:49]=[CH:50]/[C:51]([NH:31][NH:30][C:28](=[O:29])[CH:27]([C:24]2[CH:25]=[CH:26][C:21]([F:20])=[CH:22][CH:23]=2)[CH2:32][CH2:33][OH:34])=[O:52])[CH:40]=[CH:41][C:42]=1[N:43]1[CH:47]=[C:46]([CH3:48])[N:45]=[CH:44]1

참가 물질

9

반응물 4

HCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 59528030(E)-3-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]acrylic acidHCID 67067321HCID 67067321, 화합물

생성물 1

HCID 67067277HCID 67067277, 화합물수율 100.1%

시약·촉매·용매 4

HCID 111,2-Dichloroethane용매HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매HCID 57417360Sodium chloride; water용매

실험 절차

IPEA (0.17 mL), HOBT (134 mg) and EDC (190 mg) were added to a solution of 2-(4-fluorophenyl)-4-hydroxybutyric acid hydrazide (105 mg) and (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid (153 mg) in DMF (3 mL), and the reaction solution was stirred at room temperature for 14 hours. Ethyl acetate and brine were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 224 mg of the title compound. The property value of the compound is as follows.

후처리

  1. customthe organic layer was separated
  2. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9b69479f523e43a09a343333a53d8e04
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973033B2

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