Hydrazine hydrate (1:1) → methyl 5-(aminomethyl)-1-methyl-1H-pyrrole-2-carboxylate
반응식
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][C:13]1[N:17]([CH3:18])[C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15][CH:14]=1.O.NN>CO>[NH2:3][CH2:12][C:13]1[N:17]([CH3:18])[C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15][CH:14]=1참가 물질
4
실험 절차
650 mg of methyl 5-[(1,3-dioxo-1,3-dihydro-2H-isoindole-2-yl)methyl]-1-methyl-1H-pyrrole-2-carboxylate was dissolved in 20.0 mL of methanol, and 109 mg of hydrazine monohydrate was added thereto, followed by stirring at room temperature overnight. The reaction liquid was concentrated under reduced pressure, to the obtained residue was added chloroform, and the insolubles were filtered off. Then, the filtrate was concentrated under reduced pressure to obtain 294 mg of methyl 5-(aminomethyl)-1-methyl-1H-pyrrole-2-carboxylate.
후처리
- customThe reaction liquid
- concentrationwas concentrated under reduced pressure, to the obtained residue
- additionwas added chloroform
- filtrationthe insolubles were filtered off
- concentrationThen, the filtrate was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-963f5cd87b2d468b82f9b1459c63347e
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07973078B2
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