Water → 4-[(2-Hydroxyethyl)(methyl)amino]benzoic acid
반응식
[OH:1][CH2:2][CH2:3][N:4]([CH3:16])[C:5]1[CH:15]=[CH:14][C:8]([C:9]([O:11]CC)=[O:10])=[CH:7][CH:6]=1.[OH-].[Na+].O>CO>[OH:1][CH2:2][CH2:3][N:4]([CH3:16])[C:5]1[CH:15]=[CH:14][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1참가 물질
5
실험 절차
To a solution (10 ml) of ethyl 4-[(2-hydroxyethyl)(methyl)amino]benzoate (500 mg, 2.24 mmol) in methanol was added 1M aqueous sodium hydroxide solution (10 ml), and the mixture was stirred at room temperature for 3 hrs. Water was added to the reaction mixture, and the mixture was washed with diethyl ether. 1M Hydrochloric acid (10 ml) was added, and the mixture was extracted with dichloromethane and concentrated under reduced pressure to give the title compound (119 mg, 27%) as a white solid.
후처리
- washthe mixture was washed with diethyl ether
- addition1M Hydrochloric acid (10 ml) was added
- extractionthe mixture was extracted with dichloromethane
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-a1bc50762cc5449aa1bc76a9d368e6e5
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07973163B2
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