Hydrochloric Acid → 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid
반응식
OCC(CO)O.[OH-:7].[K+].[CH3:9][O:10][C:11]1[CH:20]=[C:19]2[C:14]([C:15](=[O:21])[CH:16]=[CH:17][NH:18]2)=[CH:13][C:12]=1[C:22]#N.Cl.[OH2:25]>>[CH3:9][O:10][C:11]1[CH:20]=[C:19]2[C:14]([C:15](=[O:21])[CH:16]=[CH:17][NH:18]2)=[CH:13][C:12]=1[C:22]([OH:25])=[O:7]참가 물질
6
반응 조건
- 온도
- 160 °C
실험 절차
Glycerol (20 ml) and potassium hydroxide (KOH, 3.0 g) were added to the 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carbonitrile (2 g) of Production Example 24, and after heating and stirring at 160° C. for 3 hours, water (40 ml) was added and the mixture was heated at 80° C. for 30 minutes. After cooling, 2N hydrochloric acid was added to acidity and the precipitated insoluble portion was filtered out, washed with water and then dried under reduced pressure to obtain the title compound (1.6 g).
후처리
- temperatureafter heating
- temperaturethe mixture was heated at 80° C. for 30 minutes
- temperatureAfter cooling
- filtrationthe precipitated insoluble portion was filtered out
- washwashed with water
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-d97ba597cecc4ae8b9aa76f241ccf00c
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07973160B2
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