Sodium borohydride → 5-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-ol

HRID 1010798노트

반응식

HRID 1010798 반응식
[OH:1][CH2:2][CH2:3][N:4]1[CH2:10][C:9](=[O:11])[C:6]2([CH2:8][CH2:7]2)[CH2:5]1.[BH4-].[Na+]>CO>[OH:1][CH2:2][CH2:3][N:4]1[CH2:10][CH:9]([OH:11])[C:6]2([CH2:7][CH2:8]2)[CH2:5]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 167382835-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-one

생성물 1

HCID 167382855-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-one (100 mg) was dissolved into Methanol (8 ml) and stirred at RT. NaBH4 (100 mg) was added to the reaction and stirred at RT for 30 minutes. The reaction was evaporated and purified by column chromatography to give title compound. Mass: (M+1), 158

후처리

  1. stirringstirred at RT for 30 minutes
  2. customThe reaction was evaporated
  3. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-0effb4b5009a43d2a870d2f4eaaaca35
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977346B2

반응 노트

불러오는 중…