Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-(2-Fluoro-phenyl)-3H-thieno[2,3-d]pyrimidin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-(2-Fluorobenzamido)thiophene-3-carboxamide | HCID 7164102 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 2-(2-Fluoro-phenyl)-3H-thieno[2,3-d]pyrimidin-4-one | HCID 21104303 | 68% |
반응 단계
2-(2-Fluoro-benzoylamino)-thiophene-3-carboxylic acid amide (8.56 g, 32.4 mmole) was dissolved in a mixture of 20 ml 1 M sodium hydroxide and 60 ml ethanol. The mixture was brought to reflux for 4 hours. The reaction mixture was cooled and poured onto ice. The solution was acidified with dilute hydrochloric acid and the product was isolated by filtration. Upon vacuum drying 5.42 g of product was obtained (Yield: 68%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07977342B2 |
| 출처 데이터셋 | uspto-grants-2011_07 |
| ORD ID | ord-49d4cdb32c5b44ea8d7d4212bb8dc3d0 |
| 출처 메모 | uspto-grants-2011_07 |