Trifluoroacetic acid → Mk-1496
반응식
[C:1]([NH:5][CH2:6][C@H:7]([C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([NH:17]C(=O)OC(C)(C)C)[CH3:16])=[CH:11][CH:10]=1)[OH:8])([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[NH2:17][C@H:15]([C:12]1[CH:13]=[CH:14][C:9]([C@H:7]([OH:8])[CH2:6][NH:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:10][CH:11]=1)[CH3:16]참가 물질
4
실험 절차
15.8 g of the compound [5-5] was dissolved in 50 mL of chloroform, 45 mL of trifluoroacetic acid was added thereto under an ice-cold condition, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (eluent: chloroform/methanol=100/0 to 90/10) to obtain 10.7 g of (1S)-1-{4-[(1S)-1-aminoethyl]phenyl}-2-(tert-butylamino)ethanol [67-3] (hereinafter, referred to as the compound [67-3]) as a white solid.