4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine → 4-(4-tert-Butylcyclohexylamino)-3-methoxy-2-methylpyridine

HRID 1011

반응식

HRID 1011 반응식
[C:1]([C:5]1[CH:20]=[CH:19][C:8]([NH:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[C:11]=2[O:17][CH3:18])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.Cl.O>[C:1]([CH:5]1[CH2:20][CH2:19][CH:8]([NH:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[C:11]=2[O:17][CH3:18])[CH2:7][CH2:6]1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 1

HCID 196939534-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

생성물 1

HCID 544512624-(4-tert-Butylcyclohexylamino)-3-methoxy-2-methylpyridine

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 887Methanol용매HCID 962Water용매

실험 절차

1 g of 4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine in 20 ml of methanol, 3.7 ml of 2N HCl and 1.3 ml of water are hydrogenated at room temperature and normal pressure until absorption of hydrogen has ended using 1 g of rhodium on alumina (5% strength). After filtering and concentrating 1 g of syrup remains=100% isomer mixture.

후처리

  1. customare hydrogenated at room temperature
  2. customnormal pressure until absorption of hydrogen
  3. filtrationAfter filtering
  4. concentrationconcentrating 1 g of syrup

출처 및 근거

ORD 기록
ord-61a0177588e440db829d21a8578b91c1
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723450

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