Water → 3,3-Dimethoxypropanoic acid lithium salt

HRID 10110

반응식

HRID 10110 반응식
C[O:2][C:3](=[O:10])[CH2:4][CH:5]([O:8][CH3:9])[O:6][CH3:7].O[Li:12].O.O>C1COCC1>[Li+:12].[CH3:7][O:6][CH:5]([O:8][CH3:9])[CH2:4][C:3]([O-:10])=[O:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 81924Methyl 3,3-dimethoxypropionateHCID 168937Lithium hydroxide, monohydrate

생성물 1

HCID 876652803,3-Dimethoxypropanoic acid lithium salt수율 98.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

(Related to methods described in Alabaster, C. T. et. al., J. Med. Chem. 1988, 31, 2048–2056.) 3,3-Dimethoxypropanoic acid methyl ester (14.25 g, 96.2 mmol) in THF (100 mL) was treated with LiOH.H2O (2.5 g, 106 mmol) and H2O (2 mL). The mixture was brought to reflux for 4 hours, cooled to room temperature and azeotropically dried from THF (4 times) to provide white solids (13.3 g).

후처리

  1. temperatureto reflux for 4 hours
  2. dry with materialazeotropically dried from THF (4 times)

출처 및 근거

ORD 기록
ord-1760007316da4df791d25f5e9c52543d
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091372B2

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