Hydrochloric Acid → 6-Amino-2-(butylamino)-9-[2-(tetrahydro-2H-Pyran-2-yl)ethyl]-7,9-dihydro-8H-Purin-8-one

HRID 1011175

반응식

HRID 1011175 반응식
[CH2:1]([NH:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl.O.C(=O)(O)[O-].[Na+]>CO.O1C=COC=C1>[NH2:25][C:8]1[N:7]=[C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:23])[N:12]2[CH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][O:18]1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 516892Sodium BicarbonateHCID 57699622N2-Butyl-8-(methoxy)-9-[2-(tetrahydro-2H-pyran-2-yl)ethyl]-9H-Purine-2,6-diamine

생성물 1

HCID 576996906-Amino-2-(butylamino)-9-[2-(tetrahydro-2H-Pyran-2-yl)ethyl]-7,9-dihydro-8H-Purin-8-one

시약·촉매·용매 2

HCID 887Methanol용매HCID 789681,4-Dioxin용매

실험 절차

A solution of N2-butyl-8-(methoxy)-9-[2-(tetrahydro-2H-pyran-2-yl)ethyl]-9H-purine-2,6-diamine (54 mg) in methanol (1 ml) was treated with 4N HCl in dioxin (0.5 ml) and stood for 1.5 h. The solvents were stripped and the residue treated with water and made basic with saturated aqueous sodium bicarbonate. The precipitated material was filtered, washed with water and dried to give the title compound as a solid, yield 22.5 mg.

후처리

  1. filtrationThe precipitated material was filtered
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-6838312a14de4624b0f2973c624f9431
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

연결된 노트

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