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Hydrochloric Acid → 6-Amino-2-{[(1R)-1-methylbutyl]oxy}-9-[3-(tetrahydro-3-furanyl)propyl]-7,9-dihydro-8H-purin-8-one

HRID 1011211
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HRID 1011211 반응식
[CH3:1][C@@H:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:24]C)[N:13]2[CH2:16][CH2:17][CH2:18][CH:19]2[CH2:23][CH2:22][O:21][CH2:20]2)=[C:9]([NH2:26])[N:8]=1)[CH2:3][CH2:4][CH3:5].Cl.O1CCOCC1>CO>[NH2:26][C:9]1[N:8]=[C:7]([O:6][C@H:2]([CH3:1])[CH2:3][CH2:4][CH3:5])[N:15]=[C:14]2[C:10]=1[NH:11][C:12](=[O:24])[N:13]2[CH2:16][CH2:17][CH2:18][CH:19]1[CH2:23][CH2:22][O:21][CH2:20]1
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참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 576997402-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-9H-purin-6-amine

생성물 1

HCID 250247736-Amino-2-{[(1R)-1-methylbutyl]oxy}-9-[3-(tetrahydro-3-furanyl)propyl]-7,9-dihydro-8H-purin-8-one수율 72%

시약·촉매·용매 1

HCID 887Methanol용매
2회

실험 절차

To a solution of 2-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-9H-purin-6-amine (52 mg, 0.143 mmol) in methanol (5 ml) at room temperature was added 4M HCl in dioxane (0.894 ml, 3.58 mmol). The reaction mixture was stirred at room temperature for 18 hrs and concentrated in vacuo to give a white solid. This material was dissolved in methanol and loaded onto a 2 g aminopropyl SPE cartridge, eluting with methanol. The solvent was removed to give the title compound as a white solid (36 mg).

후처리

  1. concentrationconcentrated in vacuo
  2. customto give a white solid
  3. washeluting with methanol
  4. customThe solvent was removed

출처 및 근거

ORD 기록
ord-1244044518424cdb9d17dc132078c285
출처 데이터셋
uspto-grants-2011_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07977344B2

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