Lithium Hydroxide → 5-Methoxyquinoline-3-carboxylic acid

HRID 1011429노트

반응식

HRID 1011429 반응식
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21]CC)=[O:20])[CH:13]=[N:14]2)C1C=CC=CC=1.[Li+].[OH-]>C1COCC1.O>[CH3:1][O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[C:12]([C:19]([OH:21])=[O:20])[CH:13]=[N:14]2

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 23159744HCID 23159744, 화합물

생성물 1

HCID 231597415-Methoxyquinoline-3-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of ethyl 5-methoxyquinoline-3-carboxylate (2.31 g, 10 mmol) prepared in stage B of example 2 and LiOH (0.4 g, 20 mmol) in THF (20 mL) and water (0.5 mL) was refluxed for 2 hours. After cooling, the solvents were evaporated under vacuum. The solid residue was used in the next step without further purification.

후처리

  1. temperatureAfter cooling
  2. customthe solvents were evaporated under vacuum
  3. customThe solid residue was used in the next step without further purification

출처 및 근거

ORD 기록
ord-28339260fa2744bba8e1de1f258a4b27
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977354B2

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