N-bromobutanimide → HCID 67315809, 화합물

HRID 1013305노트

반응식

HRID 1013305 반응식
[C:1]1([CH3:20])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[C:10]([C:16]([O:18][CH3:19])=[O:17])[NH:11]2.[Br:21]N1C(=O)CCC1=O>ClCCl.O1CCCC1>[Br:21][C:9]1[C:8]2[C:12](=[CH:13][CH:14]=[CH:15][C:7]=2[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[CH3:20])[NH:11][C:10]=1[C:16]([O:18][CH3:19])=[O:17]

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 67316099Methyl 4-o-tolyl-1h-indole-2-carboxylate

생성물 1

HCID 67315809HCID 67315809, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of EXAMPLE 126A (205 mg) in dichloromethane (5 ml) and tetrahydrofuran (5 ml) at 0° C. was added dropwise N-bromosuccinimide (144 mg) in tetrahydrofuran (3 ml). The mixture was stirred while the ice bath slowly reached room temperature. The reaction mixture was concentrated and the residue was dissolved in dichloromethane and purified by flash chromatography, eluting with 0-100% dichloromethane in hexane to provide the desired product.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in dichloromethane
  3. custompurified by flash chromatography
  4. washeluting with 0-100% dichloromethane in hexane

출처 및 근거

ORD 기록
ord-e970a1dd4af74878830c840d12a0a5f4
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07981888B2

반응 노트

불러오는 중…