홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium triacetoxyborohydride → HCID 178515500, 화합물

HRID 1013846
노트
인쇄 미리보기

반응식

HRID 1013846 반응식
[Br:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][CH:7]([CH2:13][CH:14]=O)[C:8]([O:10]CC)=O)=[C:4]([Cl:18])[CH:3]=1.Cl.[NH:20]1[C:28]2[CH2:27][CH:26]([NH2:29])[CH2:25][CH2:24][C:23]=2[CH:22]=[N:21]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClC(Cl)C>[Br:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][CH:7]2[CH2:13][CH2:14][N:29]([CH:26]3[CH2:27][C:28]4[C:23](=[CH:22][NH:21][N:20]=4)[CH2:24][CH2:25]3)[C:8]2=[O:10])=[C:4]([Cl:18])[CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 5049666Sodium triacetoxyborohydrideHCID 673173104,5,6,7-Tetrahydro-2H-indazol-6-amine hydrochlorideHCID 86629116Ethyl 2-(4-bromo-2-chlorobenzyl)-4-oxobutanoate

생성물 1

HCID 178515500HCID 178515500, 화합물수율 68%

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

Combine ethyl 2-(4-bromo-2-chlorobenzyl)-4-oxobutanoate (0.92 g, 2.8 mmol), 4,5,6,7-tetrahydro-1H-indazol-6-amine hydrochloride (preparation 80) (490 mg, 2.8 mmol) and sodium triacetoxyborohydride (886 mg, 4.2 mmol) in dichloroethane (50 mL) and stir for 48 hours at room temperature. Add water and extract with CH2Cl2. Dry the organic layer over magnesium sulfate, filter and concentrate. Purify the residue by silica gel chromatography affords the title compound (428 mg, 68%): MS (m/z): 410 (M+2).

후처리

  1. extractionAdd water and extract with CH2Cl2
  2. dry with materialDry the organic layer over magnesium sulfate
  3. filtrationfilter
  4. concentrationconcentrate
  5. customPurify the residue by silica gel chromatography

출처 및 근거

ORD 기록
ord-e75f9f11803d467386e428898e6c6b6c
출처 데이터셋
uspto-grants-2011_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07981918B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트