Hydrochloric Acid → 2-(Ethylsulfanyl)-5-methylbenzonitrile

HRID 1013996

반응식

HRID 1013996 반응식
F[C:2]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:3]=1[C:4]#[N:5].[CH2:11]([S-:13])[CH3:12].[Na+].Cl>CN(C)C=O>[CH2:11]([S:13][C:2]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:3]=1[C:4]#[N:5])[CH3:12]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 27745842-Fluoro-5-methylbenzonitrileHCID 4459711Sodium ethanethiolate

생성물 1

HCID 668771452-(Ethylsulfanyl)-5-methylbenzonitrile수율 87.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

(Step 1) A mixture of 2-fluoro-5-methylbenzonitrile (7.5 g) and sodium ethanethiolate (4.9 g) was stirred in N,N-dimethylformamide (30 ml) at room temperature for 3 hr. The reaction solution was treated with 1N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give 2-(ethylsulfanyl)-5-methylbenzonitrile (8.57 g).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-aadc41946eae4174ad87e33ec572923c
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07982044B2

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