Pyridine, 2-(trimethylstannyl)- → 1-Methyl-7-pyridin-2-yl-1,2,3,4-tetrahydro-isoquinoline

HRID 1015079노트

반응식

HRID 1015079 반응식
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][NH:8][CH:9]2[CH3:12])=[CH:4][CH:3]=1.C[Sn](C)(C)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1>>[CH3:12][CH:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[CH:11]=2)[CH2:6][CH2:7][NH:8]1

참가 물질

3

반응물 2

HCID 11021057Pyridine, 2-(trimethylstannyl)-HCID 584164221176414-95-1

생성물 1

HCID 584163091-Methyl-7-pyridin-2-yl-1,2,3,4-tetrahydro-isoquinoline

실험 절차

In close analogy to the procedure described above, 7-Bromo-1-methyl-1,2,3,4-tetrahydro-isoquinoline is reacted with 2-trimethylstannyl-pyridine to provide the title compound.

출처 및 근거

ORD 기록
ord-27ca52633a884246af6ec84a1aa8bc2d
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07985753B2

반응 노트

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