1,2-Dichloroethane → HCID 57889973, 화합물

HRID 1016197노트

반응식

HRID 1016197 반응식
[CH3:1][CH:2]([CH3:14])[C@@H:3]([NH:7][C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)[C:4]([OH:6])=O.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C@@:22]2([OH:30])[CH2:27][CH2:26][NH:25][CH2:24][C:23]2([CH3:29])[CH3:28])=[CH:18][CH:17]=1.C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C>CN(C=O)C>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C@@:22]2([OH:30])[CH2:27][CH2:26][N:25]([C:4](=[O:6])[C@H:3]([NH:7][C:8]3[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=3)[CH:2]([CH3:1])[CH3:14])[CH2:24][C:23]2([CH3:28])[CH3:29])=[CH:18][CH:17]=1

참가 물질

7

반응물 5

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 18437142(S)-4-(4-chlorophenyl)-3,3-dimethylpiperidin-4-olHCID 57889332HCID 57889332, 화합물

생성물 1

HCID 57889973HCID 57889973, 화합물수율 6.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

(R)-3-Methyl-2-(pyridine-3-ylamino)butanoic acid (162 mg, 0.83 mmol), (S)-4-(4-chlorophenyl)-3,3-dimethylpiperidin-4-ol (200 mg, 0.83 mmol), EDC (320 mg, 1.67 mmol), HOBT (113 mg, 0.83 mmol), DIPEA (431 mg, 3.34 mmol), and DMF (4 mL) was stirred overnight at rt. Example 607 was isolated as a greenish solid using preparative reverse phase HPLC (22.5 mg, 6.5% yield). M+H=416.18.

후처리

  1. customExample 607 was isolated as a greenish solid

출처 및 근거

ORD 기록
ord-de3f74e18e144e55997f203afcd8f56a
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07985861B2

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