Hydrochloric Acid → 4-(4-Chlorobenzyl)piperidine

HRID 1016436

반응식

HRID 1016436 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.C(=O)([O-])[O-].[Na+].[Na+]>O1CCOCC1>[Cl:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 22893851Tert-butyl 4-(4-chlorobenzyl)piperidine-1-carboxylate

생성물 1

HCID 37327804-(4-Chlorobenzyl)piperidine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 2 g of 4-(4-chloro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester, dioxane (1.5 mL), and 3N hydrochloric acid (1.0 mL, 4equiv.) was heated at reflux for 3.5 hours. The cooled mixture was made basic with saturated sodium carbonate solution and extracted with chloroform (3×10 mL). The combined extracts were dried over magnesium sulfate and concentrated under reduced pressure. The crude product (1.2 g) was an oil.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. extractionextracted with chloroform (3×10 mL)
  4. dry with materialThe combined extracts were dried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a322db343dac44d1a4ef02ca7f9d00c2
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06476041B1

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