Hydrochloric Acid → 3-[2-(Dibutylamino)ethylamino]-1-nonyl-pyrrolidine-2,5-dione

HRID 1016524노트

반응식

HRID 1016524 반응식
[CH2:1]([N:10]1[C:14](=[O:15])[CH:13]=[CH:12][C:11]1=[O:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C(N(CC)CC)C.[CH2:24]([N:28]([CH2:32][CH2:33][CH2:34][CH3:35])[CH2:29][CH2:30][NH2:31])[CH2:25][CH2:26][CH3:27].Cl>C(#N)C.C(OCC)(=O)C>[CH2:24]([N:28]([CH2:32][CH2:33][CH2:34][CH3:35])[CH2:29][CH2:30][NH:31][CH:13]1[CH2:12][C:11](=[O:16])[N:10]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[C:14]1=[O:15])[CH2:25][CH2:26][CH3:27]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 77062N,N-DibutylethylenediamineHCID 512831N-Nonylmaleimide

생성물 1

HCID 5128573-[2-(Dibutylamino)ethylamino]-1-nonyl-pyrrolidine-2,5-dione

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 8857Ethyl Acetate용매

실험 절차

N-nonyl maleimide (0.02 mM) prepared as described in Example 12 above in 2 ml of acetonitrile was treated with one equivalent of triethylamine and one equivalent of N,N-dibutylethylenediamine. The reaction mixture was stirred for six hours and then the acetonitrile was evaporated. The residue obtained was treated with cold aqueous dilute hydrochloric acid solution and ethyl acetate, with stirring for one hour. The ethyl acetate layer was then separated and concentrated to give the desired product.

후처리

  1. customthe acetonitrile was evaporated
  2. customThe residue obtained
  3. stirringwith stirring for one hour
  4. customThe ethyl acetate layer was then separated
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d2a58ec7360943a4acba299008de7e77
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06476053B1

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