4-(Methanesulfonyl)-3-nitrobenzoic acid → 3-Amino-4-methylsulfonylbenzoic acid

HRID 1017125노트

반응식

HRID 1017125 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([OH:9])=[O:8])([O-])=O.[H][H]>[Ni].CO>[NH2:1][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([OH:9])=[O:8]

참가 물질

5

반응물 2

HCID 27238714-(Methanesulfonyl)-3-nitrobenzoic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 227288903-Amino-4-methylsulfonylbenzoic acid

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

0.447 mol of 3-nitro-4-methylsulfonylbenzoic acid was reduced with hydrogen by employing 100 g of Raney nickel in 2.5 l of methanol. The mixture was then heated to reflux and filtered off hot with suction. The filtrate was concentrated.

후처리

  1. temperatureThe mixture was then heated
  2. temperatureto reflux
  3. filtrationfiltered off hot with suction
  4. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-93a46b0ed8fb46ea8f5d878cb19bb8f1
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479436B1

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