Guaiacol → ((o-Methoxyphenoxy)methyl)oxirane

HRID 1017247노트

반응식

HRID 1017247 반응식
[C:1]1([O:8][CH3:9])[C:2](=[CH:4][CH:5]=[CH:6][CH:7]=1)[OH:3].CC(C)([O-])C.[K+].[CH2:16]([CH:18]1[O:20][CH2:19]1)Cl.C1OCCOCCOCCOCCOCCOC1>C(O)(C)(C)C.O>[O:20]1[CH2:19][CH:18]1[CH2:16][O:3][C:2]1[CH:4]=[CH:5][CH:6]=[CH:7][C:1]=1[O:8][CH3:9]

참가 물질

7

반응물 4

HCID 460GuaiacolHCID 7835EpichlorohydrinHCID 2855718-Crown-6HCID 23665647Potassium tert-butoxide

생성물 1

HCID 98357((o-Methoxyphenoxy)methyl)oxirane

시약·촉매·용매 2

HCID 962Water용매HCID 6386tert-Butanol용매

반응 조건

온도
50 °C

실험 절차

Guaiacol (8.6 g, 69 mmol), potassium t-butoxide (7.8 g, 69 mmol), epichlorohydrin (19.3 g, 209 mmol), and 18-crown-6 (0.8 g) were mixed in t-butanol (100 ml) and heated to 50° C. for 2 h. Water was added and the product was extracted with two portions of dichlorometane. Washing with water, twice, was followed by drying and evaporation. Quantitative yield.

후처리

  1. extractionthe product was extracted with two portions of dichlorometane
  2. washWashing with water
  3. customby drying
  4. customevaporation

출처 및 근거

ORD 기록
ord-7f06efcd61404ef7987c209d8f77713a
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479491B1

반응 노트

불러오는 중…