Iodoethane → 4-Ethoxy-2-(2'-methoxyphenyl)quinazoline

HRID 1017540노트

반응식

HRID 1017540 반응식
CO[C:3]1[C:12]2C(=CC=CC=2)N=C(C2C=CC=CC=2)N=1.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[NH:36][C:35](=[O:37])[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[N:28]=1.C(I)C>>[CH2:3]([O:37][C:35]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[N:28]=[C:27]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[O:20][CH3:19])[N:36]=1)[CH3:12]

참가 물질

4

반응물 3

HCID 6340IodoethaneHCID 6168674-Methoxy-2-phenylquinazolineHCID 1354360052-(2-methoxyphenyl)-3H-quinazolin-4-one

생성물 1

HCID 184039574-Ethoxy-2-(2'-methoxyphenyl)quinazoline수율 84.1%

실험 절차

According to the preparation of 69, 42 (1.13 g, 4.5 mmol) and ethyl iodide (1.40 g, 9.00 mmol) was used to yield 74 (1.06 g, 84.1%) as colorless powder.

출처 및 근거

ORD 기록
ord-7ec24328b2f844baa5b8e4901fcec418
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479499B1

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