Lithium hydroxide, monohydrate → 2-(3-(Morpholin-4-yl)phenyl)acetic acid

HRID 1017566

반응식

HRID 1017566 반응식
[N:1]1([C:7]2[CH:8]=[C:9]([CH2:13][C:14]([O:16]C)=[O:15])[CH:10]=[CH:11][CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O.[OH-].[Li+]>CO.O>[N:1]1([C:7]2[CH:8]=[C:9]([CH2:13][C:14]([OH:16])=[O:15])[CH:10]=[CH:11][CH:12]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 18403524Methyl 3-(morpholin-4-yl)phenylacetate

생성물 1

HCID 184034952-(3-(Morpholin-4-yl)phenyl)acetic acid수율 90.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of methyl 3-(morpholin-4-yl)phenylacetate (0.50 g, 2.1 mmol) in methanol (5 mL) and H2O (1 mL) was added lithium hydroxide monohydrate (0.18 g, 2 eq.). After the reaction mixture was stirred at room temperature overnight, it was concentrated to dryness. Acetic acid was then added to the residue and the resulting mixture was partitioned between EtOAc and H2O. The organic layer was washed with NaCl (sat.), dried over Na2SO4, and evaporation under vacuo to give 3-(morpholin-4-yl)phenylacetic acid (0.42 g).

후처리

  1. concentrationit was concentrated to dryness
  2. additionAcetic acid was then added to the residue
  3. customthe resulting mixture was partitioned between EtOAc and H2O
  4. washThe organic layer was washed with NaCl (sat.)
  5. dry with materialdried over Na2SO4, and evaporation under vacuo

출처 및 근거

ORD 기록
ord-7f308cfca37b4e56b5b18d8b5d2b2669
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479490B2

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