Sodium Hydroxide → 3-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one

HRID 1017743

반응식

HRID 1017743 반응식
[CH3:1][CH:2]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([CH3:13])=[O:12])=[CH:7][CH:6]=1)[CH3:3].[CH2:14]([N:21]1[C:25]([CH:26]=O)=[CH:24][N:23]=[CH:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[OH-].[Na+]>CO>[CH2:14]([N:21]1[C:25]([CH:26]=[CH:13][C:11]([C:8]2[CH:7]=[CH:6][C:5]([CH2:4][CH:2]([CH3:1])[CH3:3])=[CH:10][CH:9]=2)=[O:12])=[CH:24][N:23]=[CH:22]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 932144'-IsobutylacetophenoneHCID 27732391-Benzyl-1H-imidazole-5-carboxaldehyde

생성물 1

HCID 537079343-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 4-isobutylacetophenone (2.0 g), 3-benzyl-3H-imidazole-4-carbaldehyde (2.1 g) and 48% sodium hydroxide (0.65 ml) in methanol (20 ml) is heated at 55-60° C. for 6 hours. The reaction mixture is then cooled in an ice bath. The resulting precipitate is filtered, and rinsed with methanol. The yield is 2.5 g.

후처리

  1. temperatureThe reaction mixture is then cooled in an ice bath
  2. filtrationThe resulting precipitate is filtered
  3. washrinsed with methanol

출처 및 근거

ORD 기록
ord-ac275b4941a24169bdd390a2461dec08
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479530B2

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