HCID 178418361, 화합물 → HCID 178486573, 화합물

HRID 1017749

반응식

HRID 1017749 반응식
[NH:1]1[CH:5]=[C:4]([CH:6]2[C:14]3[C:9](=[C:10]([CH3:18])[C:11]([CH3:17])=[C:12]([O:15][CH3:16])[CH:13]=3)[CH:8](O)[CH2:7]2)[N:3]=[CH:2]1.[H][H]>C(O)C.Cl.[Pd]>[CH3:16][O:15][C:12]1[CH:13]=[C:14]2[C:9]([CH2:8][CH2:7][CH:6]2[C:4]2[N:3]=[CH:2][NH:1][CH:5]=2)=[C:10]([CH3:18])[C:11]=1[CH3:17]

참가 물질

6

반응물 2

HCID 178418361HCID 178418361, 화합물HCID 178486576HCID 178486576, 화합물

생성물 1

HCID 178486573HCID 178486573, 화합물

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

3-(1H-Imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-ol (0.29 g) is dissolved in the mixture of ethanol (30 ml) and concentrated hydrochloric acid (0.2 ml). The solution is hydrogenated at 50-55° C. with 10% palladium on carbon as catalyst until no more hydrogen is consumed. The mixture is filtered and the filtrate is evaporated to dryness. The residue is crystallized from the mixture of ethyl acetate and ethanol. M.p. of the hydrochloride salt is 174-177° C.

후처리

  1. customis consumed
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated to dryness
  4. customThe residue is crystallized from the mixture of ethyl acetate and ethanol
  5. customis 174-177° C.

출처 및 근거

ORD 기록
ord-0c3feb80b17743559748952c902e3985
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479530B2

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