Sodium Hydroxide → 2,2-dimethyl-N-[(1R)-1-phenylethyl]propanamide

HRID 1018526노트

반응식

HRID 1018526 반응식
[OH-].[Na+].[C:3]1([C@H:9]([NH2:11])[CH3:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:12](Cl)(=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14]>O>[C:3]1([C@H:9]([NH:11][C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[CH3:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 62493Pivaloyl chlorideHCID 6431891-Phenethylamine, (+)-

생성물 1

HCID 69517442,2-dimethyl-N-[(1R)-1-phenylethyl]propanamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In 1,300 ml of water is dissolved 130 g of sodium hydroxide and in the solution is suspended 188 g of (1R)-1-phenylethylamine, after which 287 ml of pivaloyl chloride is dropwise added to the suspension at 20° C. over 40 minutes. The resulting mixture is stirred at the same temperature for 1.5 hours and the crystals deposited are collected by filtration to obtain 289 g of N-[(1R)-1-phenylethyl]-2,2-dimethylpropanamide.

후처리

  1. filtrationthe crystals deposited are collected by filtration

출처 및 근거

ORD 기록
ord-2875b8331db24e348e0f03fc48e0dff8
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06482835B2

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