Hydrochloric Acid → HCID 68434078, 화합물

HRID 1018541노트

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HRID 1018541 반응식
C(O)C.[CH:4]1([N:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:21]4[CH:22]=[C:23]5[C:27](=[CH:28][CH:29]=4)[C@@H:26]([CH3:30])[NH:25][CH2:24]5)[C:15]=3[O:17][CH:18]([F:20])[F:19])[C:10](=[O:31])[C:9]([C:32]([OH:34])=[O:33])=[CH:8]2)[CH2:6][CH2:5]1.[ClH:35]>O>[ClH:35].[CH:4]1([N:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:21]4[CH:22]=[C:23]5[C:27](=[CH:28][CH:29]=4)[C@@H:26]([CH3:30])[NH:25][CH2:24]5)[C:15]=3[O:17][CH:18]([F:20])[F:19])[C:10](=[O:31])[C:9]([C:32]([OH:34])=[O:33])=[CH:8]2)[CH2:6][CH2:5]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 124093Garenoxacin

생성물 1

HCID 68434078HCID 68434078, 화합물

시약·촉매·용매 1

HCID 962Water용매

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온도
50 °C

실험 절차

In 20 ml of 50% water-containing ethanol is suspended 1.0 g of (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid and the suspension is then warmed to 50° C., after which 0.41 ml of 6 moles/liter hydrochloric acid is added thereto to form a uniform solution. Subsequently, the solution is stirred at the same temperature for 10 minutes and then filtered. The filtrate is cooled to room temperature and the crystals deposited are thereafter collected by filtration to obtain 0.56 g of (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride.

후처리

  1. customto form a uniform solution
  2. filtrationfiltered
  3. temperatureThe filtrate is cooled to room temperature
  4. filtrationthe crystals deposited are thereafter collected by filtration

출처 및 근거

ORD 기록
ord-170169f242054112a4d5e39047371321
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06482835B2

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