Hydrochloric Acid → 2-Amino-3-cycloheptylpropanoic acid
반응식
C([O:5][C:6](=[O:30])[CH:7]([N:16]=C(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:8][CH:9]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)(C)(C)C.Cl>CO>[NH2:16][CH:7]([CH2:8][CH:9]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[C:6]([OH:30])=[O:5]참가 물질
4
실험 절차
To a solution of 2-(Benzhydrylidene-amino)-3-cycloheptyl-propionic acid tert-butyl ester (1.34 g; 3.31 mmol) in methanol (5 mL) was added 10N HCl solution (15 mL) and the mixture heated to reflux. After 15 h, the mixture was allowed to cool to room temperature and transferred to a separatory funnel and washed with ethyl acetate. The aqueous layer was then neutralized with concentrated ammonium hydroxide solution and the white solid was filtered off and air dried to give 329 mg of 2-Amino-3-cycloheptyl-propionic acid.
후처리
- temperaturethe mixture heated to reflux
- customtransferred to a separatory funnel
- washwashed with ethyl acetate
- filtrationthe white solid was filtered off
- customair dried
출처 및 근거
- ORD 기록
- ord-91989a8bdd7242319ae9b2738ae692c3
- 출처 데이터셋
- uspto-grants-2002_11
- 특허 번호
- US06482951B2
반응 노트
불러오는 중…