Hydrochloric Acid → 2-Amino-3-cyclooctylpropanoic acid

HRID 1018852노트

반응식

HRID 1018852 반응식
C([O:5][C:6](=[O:31])[CH:7]([N:17]=C(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:8][CH:9]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)(C)(C)C.Cl>CO.O>[NH2:17][CH:7]([CH2:8][CH:9]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[C:6]([OH:31])=[O:5]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 865854002-(Benzhydrylidene-amino)-3-cyclooctyl-propionic acid tert-butyl ester

생성물 1

HCID 184021902-Amino-3-cyclooctylpropanoic acid수율 62.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of 2-(Benzhydrylidene-amino)-3-cyclooctyl-propionic acid tert-butyl ester (2.00 g) in methanol (15 mL) was added 10N HCl solution (30 mL) and the mixture heated to reflux. After 20 h, the mixture was allowed to cool to room temperature, diluted with 20 mL of water, transferred to a separatory funnel and washed with ethyl acetate. The aqueous layer was then neutralized with 10N sodium hydroxide solution and further cooled to 0° C. The white solid was filtered off and air dried to give 590 mg of 2-Amino-3-cyclooctyl-propionic acid.

후처리

  1. temperaturethe mixture heated to reflux
  2. customtransferred to a separatory funnel
  3. washwashed with ethyl acetate
  4. temperaturefurther cooled to 0° C
  5. filtrationThe white solid was filtered off
  6. customair dried

출처 및 근거

ORD 기록
ord-cc013cc989034414829e764675829ac3
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06482951B2

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