Ammonium formate → 4-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine

HRID 1018987노트

반응식

HRID 1018987 반응식
[C:1]([N:4]1[CH2:9][CH:8]=[C:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].C([O-])=O.[NH4+]>CO.[Pd]>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 2723923Ammonium formate2회HCID 183997764-(1-Acetyl-1,2,3,6-tetrahydropyridin-4-yl)furo[3,2-c]pyridine

생성물 1

HCID 183997294-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine

시약·촉매·용매 2

HCID 23938Palladium촉매2회HCID 887Methanol용매

실험 절차

0.7 g of Pd/C (10%) is added to a solution of 3.4 g of the product obtained in Step C and 4.4 g of ammonium formate in 150 ml of anhydrous methanol under a stream of argon. After refluxing for 45 minutes, the reaction mixture is cooled, 4.4 g of ammonium formate and 0.2 g of Pd/C (10%) are added, and the reaction mixture is then heated at reflux for 30 minutes. After returning to ambient temperature, filtration over Celite and concentration under reduced pressure, the residue is taken up in water and then extracted with dichloromethane. The expected product is isolated by extraction, drying, filtration and concentration under reduced pressure.

후처리

  1. temperatureAfter refluxing for 45 minutes
  2. temperaturethe reaction mixture is cooled
  3. temperaturethe reaction mixture is then heated
  4. temperatureat reflux for 30 minutes
  5. customAfter returning to ambient temperature
  6. filtrationfiltration
  7. concentrationover Celite and concentration under reduced pressure
  8. extractionextracted with dichloromethane

출처 및 근거

ORD 기록
ord-b0a5f0e040c14630a5e0b2bf9cefc1c3
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06486171B2

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