4-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine → 4-(4-Piperidinyl)furo[3,2-c]pyridine

HRID 1018988노트

반응식

HRID 1018988 반응식
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:6][CH2:5]1)(=O)C>Cl>[NH:4]1[CH2:5][CH2:6][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:8][CH2:9]1

참가 물질

3

반응물 1

HCID 183997294-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine

생성물 1

HCID 183997754-(4-Piperidinyl)furo[3,2-c]pyridine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 2.7 g of the product obtained in Step D in 80 ml of HCl (4N) is heated at 100° C. for 12 hours and then cooled, washed with ether, and rendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution. After extraction with dichloromethane, the organic phase is dried, filtered and then evaporated to dryness enabling the expected product to be obtained.

후처리

  1. temperaturecooled
  2. washwashed with ether
  3. additionrendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution
  4. extractionAfter extraction with dichloromethane
  5. customthe organic phase is dried
  6. filtrationfiltered
  7. customevaporated to dryness
  8. customto be obtained

출처 및 근거

ORD 기록
ord-1a40daa6276a4ceb915aa63c280c7240
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06486171B2

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