Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4'-(2,4,5-Triphenylimidazol-1-yimethyl)biphenyl-2-sulfonic Acid Dimethylaminomethylenamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2,4,5-Triphenylimidazole | HCID 10232 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4'-Bromomethylbiphenyl-2-sulfonic acid dimethylaminomethylenamide | HCID 54161706 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4'-(2,4,5-Triphenylimidazol-1-yimethyl)biphenyl-2-sulfonic Acid Dimethylaminomethylenamide | HCID 70144593 | 94.2% |
반응 단계
1.5 g of 2,4,5-triphenylimidazole, 1.9 g of 4′-bromomethylbiphenyl-2-sulfonic acid dimethylaminomethylenamide (J. Med. Chem. 1995, 38, 2357) and 2.1 g of K2CO3 are stirred at RT for 6 days in 50 ml of DMF. The reaction mixture is poured onto 300 ml of water and extracted with 500 ml of EA. The organic phase is washed 3 times with 250 ml of a saturated aqueous NaCl solution each time and dried over Na2SO4, and the solvent is removed in vacuo. 2.8 g of a viscous oil are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06486189B2 |
| 출처 데이터셋 | uspto-grants-2002_11 |
| ORD ID | ord-3458c25227a24674bb2c91b9a570733a |
| 출처 메모 | uspto-grants-2002_11 |