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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Water → 2-(1,4-Bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-1-(2-methyl-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl)-ethanone

HRID 1019640
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인쇄 미리보기

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HRID 1019640 반응식
C(O[C:4](=[O:25])[CH2:5][C:6]1[N:7]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[N:10]=1)C.Cl.[CH3:27][C:28]1[O:29][C:30]2[CH2:31][NH:32][CH2:33][CH2:34][C:35]=2[N:36]=1.CCN(C(C)C)C(C)C.O>CN1C(=O)CCC1>[F:24][C:21]1[CH:20]=[CH:19][C:18]([N:7]2[CH:8]=[C:9]([C:11]3[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=3)[N:10]=[C:6]2[CH2:5][C:4]([N:32]2[CH2:33][CH2:34][C:35]3[N:36]=[C:28]([CH3:27])[O:29][C:30]=3[CH2:31]2)=[O:25])=[CH:23][CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 86687938(1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid ethyl esterHCID 866879402-Methyl-4,5,6,7-tetrahydrooxazolo[5,4-c]pyridine;hydrochloride

생성물 1

HCID 716042642-(1,4-Bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-1-(2-methyl-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl)-ethanone수율 19.1%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

70 mg (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid ethyl ester, 55 mg 2-methyl-4,5,6,7-tetrahydro-oxazolo[5,4-c]pyridine hydrochloride and 0.1 mL DIPEA in 2 mL NMP was stirred 50 min at 180° C. under microwave condition. The reaction was poured into water and extracted with EtOAC. The organic layer was dried with magnesium sulfate and evaporated the residue was purified by HPLC (Waters Symmetry 50×140 mm water+0,3% HCOOH/methanoll 10% until 90% in 14 min) to yield 17 mg desired product. Rt: 1.10 (method A), (M+H)+: 435

후처리

  1. extractionextracted with EtOAC
  2. dry with materialThe organic layer was dried with magnesium sulfate
  3. customevaporated the residue
  4. customwas purified by HPLC (Waters Symmetry 50×140 mm water+0,3% HCOOH/methanoll 10% until 90% in 14 min)

출처 및 근거

ORD 기록
ord-2121e5c0a1d44fe89f5505877636c703
출처 데이터셋
uspto-grants-2014_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08716277B2

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