Lithium Hydroxide → HCID 61728386, 화합물

HRID 1020016노트

반응식

HRID 1020016 반응식
[CH3:1][N:2]([CH3:20])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[CH:13]=[CH:12][C:11]([C:16]([O:18]C)=[O:17])=[CH:10]2)=[CH:5][CH:4]=1.[OH-].[Li+]>CO.O>[CH3:1][N:2]([CH3:20])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[CH:13]=[CH:12][C:11]([C:16]([OH:18])=[O:17])=[CH:10]2)=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 68154733HCID 68154733, 화합물

생성물 1

HCID 61728386HCID 61728386, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

After 357 mg (1.31 mmol) of methyl 1-(4-dimethylaminophenyl)-1,6-dihydro-6-oxo-3-pyridinecarboxylate was dissolved in 12 mL of methanol and 4 mL of water, 94 mg (3.93 mmol) of lithium hydroxide was added to the solution. Afterward, the resulting reaction solution was stirred at about 50° C. for about 5 hours. After termination of the reaction was determined by liquid chromatography, the solvent was removed in vacuo, and aqueous HCl was then added to the reaction solution to titrate until a neutral solution was obtained. The resulting solid compound was filtrated and used in Example 113-3 without an additional purification process.

후처리

  1. customAfterward, the resulting reaction solution
  2. customthe solvent was removed in vacuo, and aqueous HCl
  3. additionwas then added to the reaction solution
  4. customwas obtained
  5. filtrationThe resulting solid compound was filtrated

출처 및 근거

ORD 기록
ord-76e9f618f7094176bbf5e6757e406dd0
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716309B2

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