Hydrochloric Acid → HCID 24759348, 화합물

HRID 1020204노트

반응식

HRID 1020204 반응식
[NH2:1][C:2]1[C:3]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([I:17])=[CH:13][C:12]=2[F:18])=[CH:4][C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.[CH:19]1([S:22](Cl)(=[O:24])=[O:23])[CH2:21][CH2:20]1.Cl>N1C=CC=CC=1>[F:18][C:12]1[CH:13]=[C:14]([I:17])[CH:15]=[CH:16][C:11]=1[NH:10][C:3]1[C:2]([NH:1][S:22]([CH:19]2[CH2:21][CH2:20]2)(=[O:24])=[O:23])=[CH:7][N:6]([CH3:8])[C:5](=[O:9])[CH:4]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 2760919Cyclopropanesulfonyl chlorideHCID 58990848HCID 58990848, 화합물

생성물 1

HCID 24759348HCID 24759348, 화합물수율 79%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 5-amino-4-(2-fluoro-4-iodophenylamino)-1-methylpyridin-2(1H)-one (62.3 mg, 0.174 mmol) in dry pyridine (3 mL) at 0° C. (ice-salt bath), was added cyclopropanesulfonyl chloride (29 mg, 0.206 mmol). The resultant reaction mixture was allowed to warm to room temperature and stirred for 16 hours. Aqueous HCl (1N) (5 mL) was added and the mixture stirred for 15 minutes, resulting in the formation of a precipitate which was isolated by filtration, dried under vacuum, to afford the desired compound as a tan solid. (64 mg, 79% yield)

후처리

  1. customThe resultant reaction mixture
  2. stirringthe mixture stirred for 15 minutes
  3. customresulting in the formation of a precipitate which
  4. customwas isolated by filtration
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-af69f244a27c40849b4455bc03b25aae
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716318B2

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