Sodium Hydroxide → 2-(3-(3,4-Dichlorobenzyl)ureido)thiazole-4-carboxylic acid

HRID 1020265노트

반응식

HRID 1020265 반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH:22]=[CH:23][C:24]=1[Cl:25])[CH2:7][NH:8][C:9](=[O:21])[NH:10][C:11]1[S:12][CH:13]=[C:14]([C:16]([O:18]CC)=[O:17])[N:15]=1>C(O)C>[Cl:3][C:4]1[CH:5]=[C:6]([CH:22]=[CH:23][C:24]=1[Cl:25])[CH2:7][NH:8][C:9](=[O:21])[NH:10][C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86622748Ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate

생성물 1

HCID 866227642-(3-(3,4-Dichlorobenzyl)ureido)thiazole-4-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium hydroxide (24 mL, 24 mmol, 1N in water) was added to an ethanol (50 mL) solution of ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate (Example 38) (1.8 g, 4.8 mmol). The mixture was stirred overnight. The ethanol was removed by evaporation and the aqueous solution was filtered then the filter was washed with water (20 ml). The pH of the filtrate was adjusted to less than three with concentrated HCl. The precipitate was filtered, washed with water and dried to afford 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylic acid.

후처리

  1. customThe ethanol was removed by evaporation
  2. filtrationthe aqueous solution was filtered
  3. washthe filter was washed with water (20 ml)
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-c18c43db4e9044b3bab7eb91dc18b865
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716320B2

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